A project powered by Europe
By pooling the knowledge and capacities of the members of the consortium, the PERSONALIS project aims to facilitate the diagnosis of rare diseases.
Home - PERSONALIS - Plateforme de médecine personnalisée - Université de Strasbourg
A dynamic team
On September 1, 2019, the INTERREG 3.2 PERSONALIS project was launched, a personalized medicine platform for patients with autoimmune diseases. The project is part of the specific objective 3 of the INTERREG V Upper Rhine program, "Increase the number of applications and innovations developed by cross-border consortia of the Rhine" which will make it possible to develop an IT platform for medicines and clinicians treating autoimmune diseases. Each project partner will contribute to the construction of this common IT base.
The problem
Auto-Immune Disease (AID) is the 3rd cause of morbidity in Western countries. They predominantly affect young adults and women of childbearing age. More than 40 million people are affected in Europe.
AID associates genetic and environmental factors still poorly understood, and a symptomatology which often does not allow to propose a relevant diagnosis in time.
Today, the treatments offered by clinicians are increasingly oriented towards the field of. “Targeted therapies”. This field is concerned with the level of molecular structure and biological information to the molecular mechanisms at the origin of diseases (mechanisms that may be different from one patient to another with the same disease according to the traditional classification) of patients. It therefore requires a rigorous diagnosis. Unfortunately, there are still no tools and databases that allow it to discriminate patients at this level of precision.
This problem of low molecular stratification of patients is the object of this project, thus PERSONALIS: pour un personalized medicine has been created.
The target : a personalized Medicine
To respond to this problem, it is essential to develop and bring to the clinic new tools allowing a biological stratification of patients in order to improve the diagnosis, the prognosis and to better adapt the new treatments for patients with AID. .
Our project will allow the development of a common and shared platform that will facilitate the biological stratification of patients and optimize their care. The development of this medical "toolbox" will require the expertise of each of the partners and will be carried out through two simultaneous, selective and informative strategies.
- Generate high-throughput data on a selection of informative patients from the LBBR and RARENET cohort biobanks etc.
Improve physiopatological knowledge in optics to develop new targeted treatments and / or better adapt them
A third objective is to centralize the data generated in an integrated database to which the detailed and anonymised clinical-biological characteristics of the patients will be associated. This will constitute a basis for the development of an integrated platform with UI intended for clinicians.
The consortium
This consortium, a set of Universities and Hospitals, is mobilizing to fight rare diseases! It is composed of
- University of Strasbourg ( Coordinator )
- Universitätsklinikum Freiburg
- Universitätsmedizin Mainz
- Fachhochschule Nordwestschweiz (Basel/Muttenz)
Motivations
The PERSONALIS project is part of an approach already initiated by its coordinator Prof. Thierry MARTIN at the National Reference Center for Rare Auto-immune and Systemic Diseases in Strasbourg (RESO) through the PACIFIC project, a project dedicated to the creation of an innovative new-generation medical research and care center entirely devoted to immune-mediated inflammatory diseases (IMID). This dual impetus is the mark of the profound changes taking place within healthcare establishments in the field of personalized medicine.
Our action
They materialize in research and are assessed through publications.
But also through a patient analysis using a questionnaire.
Thanks to the collaboration of partners, offer a platform to help diagnose and treat rare diseases..
Our partners
On both sides of the Rhine, our partners are mainly research centers in medicine.
Made up of European university hospitals, they collaborate with the Swiss to create a decision support platform.